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Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7 subtype viruses?

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract:

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutininstalk domain are in development.Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directedIt seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restrictedto the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses.

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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characterization and evaluation of mesoporous activated carbons from agricultural waste: Jerusalem artichoke stalk

Lei YU,Chen TU,Yongming LUO

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 2,   Pages 206-215 doi: 10.1007/s11783-014-0631-7

Abstract: This work explores the feasibility of Jerusalem artichoke stem (JAS), an agricultural waste, as an alternative precursor for fabrication of mesoporous activated carbon (MAC) via conventional ZnCl activation. The as-prepared JAS-MACs were characterized by thermogravimetric, nitrogen gas adsorption isotherm and high resolution scanning electron microscopy analysis. The interacting effects of chemical dosage, activation temperature and time on the mesoporosity, mesopore volume and carbon yield were investigated, and further optimized by response surface methodology (RSM). The Brunauer-Emmett-Teller surface area, mesoporosity and mesopore volume of the JAS-MAC prepared under optimum condition were identified to be 1631 m ·g , 90.16% and 1.11 cm ·g , respectively. Compared with commercial activated carbons, this carbon exhibited a comparable monolayer adsorption capacity of 374.5 mg·g for Methylene Blue dye. The findings suggest that RSM could be an effective approach for optimizing the pore structure of fabricated activated carbons.

Keywords： mesoporous activated carbon     response surface methodology     adsorption isotherm     agricultural wastes    

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Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 149-159 doi: 10.1007/s11684-020-0764-y

Abstract: Some novel epitopes hidden in the hemagglutinin (HA) trimeric interface have been discovered recently

Keywords： influenza virus     neutralizing antibody     hemagglutinin     globular head region     trimeric interface    

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Reuse Application on Alter-property of Plant (straw stalk) Fiber

Luo Xuegang

Strategic Study of CAE 2004, Volume 6, Issue 6,   Pages 91-94

Abstract: paper summarized the study on the technology of assist-expansion and alter-property on plant (straw stalk

Keywords： technicel innovation     plant fiber     straw stalk     alter-property     reuse application    

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Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 507-527 doi: 10.1007/s11684-020-0814-5

Abstract: The avian influenza A (H7N9) virus is a zoonotic virus that is closely associated with live poultry markets. It has caused infections in humans in China since 2013. Five waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017. H7N9 with low-pathogenicity dominated in the first four waves, whereas highly pathogenic H7N9 influenza emerged in poultry and spread to humans during the fifth wave, causing wide concern. Specialists and officials from China and other countries responded quickly, controlled the epidemic well thus far, and characterized the virus by using new technologies and surveillance tools that were made possible by their preparedness efforts. Here, we review the characteristics of the H7N9 viruses that were identified while controlling the spread of the disease. It was summarized and discussed from the perspectives of molecular epidemiology, clinical features, virulence and pathogenesis, receptor binding, T-cell responses, monoclonal antibody development, vaccine development, and disease burden. These data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging viruses, such as SARS-CoV-2.

Keywords： H7N9     HPAIV     epidemiology     clinical features     pathogenesis     hemagglutinin     immunity     vaccine    

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Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum Article

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Engineering 2024, Volume 32, Issue 1,   Pages 42-57 doi: 10.1016/j.eng.2023.08.001

Abstract: computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin

Keywords： COBRA     Influenza A     Salmonella     Vaccine     Broad spectral protection    

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Title Author Date Type Operation

Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7 subtype viruses?

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

characterization and evaluation of mesoporous activated carbons from agricultural waste: Jerusalem artichoke stalk

Lei YU,Chen TU,Yongming LUO

Journal Article

Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Journal Article

Reuse Application on Alter-property of Plant (straw stalk) Fiber

Luo Xuegang

Journal Article

Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Journal Article

Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Journal Article